口腔潜在恶性疾病和口腔癌中的免疫微环境:叙述性审查
Aiman Ali1, Graziella Rigueira Molska1, Huiling Yeo1
1Faculty of Dentistry, University of Toronto, Toronto, ON M5G1G6, Canada.
International journal of molecular sciences
|July 29, 2025
概括
瘤免疫微环境 (TIME) 显著影响口腔状细胞癌 (OSCC) 的进展和入侵. 了解免疫细胞通信是开发有效OSCC治疗的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 口腔癌研究 在口腔癌研究.
背景情况:
- 瘤免疫微环境 (TIME) 越来越多地被认为对口腔状细胞癌 (OSCC) 的作用.
- 关键的细胞组件,如淋巴细胞,巨细胞和中性粒细胞,以及炎症机制,是OSCC入侵的核心.
- 在OSCC各个阶段,从发病到转移,都观察到一致的TIME影响模式.
研究的目的:
- 审查TIME对口腔潜在恶性疾病 (OPMDs) 到OSCC的进展的影响.
- 分析免疫细胞在时间内在OSCC入侵和转移中的作用.
- 讨论OSCC免疫治疗的最新进展以及增强免疫反应的策略.
主要方法:
- 在OSCC中调查时间的研究的文献综述.
- 对免疫细胞亚型及其在OSCC进展中的分子机制的分析.
- 对OSCC的免疫疗法策略的当前知识的综合.
主要成果:
- 时间极大地影响OSCC的所有阶段,包括瘤开始,生长,入侵和转移.
- 特定的免疫细胞亚型及其分泌的信号分子扮演着多样而重要的角色.
- 了解免疫细胞与瘤细胞的通信对于治疗的发展至关重要.
结论:
- 时间是OSCC进展和侵入性的关键决定因素.
- 针对TIME内的免疫细胞相互作用,为OSCC提供了有前途的治疗途径.
- 对OSCC免疫疗法的进一步研究对于改善患者的治疗结果至关重要.
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