放射学在特征瘤缺氧的使用
Mohan Huang1, Helen K W Law2, Shing Yau Tam1
1School of Medical and Health Sciences, Tung Wah College, Hong Kong SAR, China.
International journal of molecular sciences
|July 29, 2025
概括
瘤缺氧是癌症进展的关键因素,可以使用放射学进行非侵入性评估. 这种方法提取了定量成像特征,以帮助诊断和治疗缺氧瘤的策略.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 无线电学 (Radiomics) 是一种辐射学.
背景情况:
- 瘤缺氧,以有限的氧气为特征,与增加的癌症攻击性,转移和治疗抵抗性相关.
- 传统的缺氧评估方法往往具有侵入性,并且在常规临床使用中不切实际.
- 放射学提供了一种非侵入性的替代方法,用于从医学图像中评估瘤缺氧.
研究的目的:
- 探索放射学在评估瘤缺氧中的作用.
- 讨论各种成像技术和机器学习应用在放射学中用于缺氧检测.
- 突出挑战和未来的方向在低氧瘤中放射学的临床翻译.
主要方法:
- 对成像方法的审查,包括MRI,PET和CT用于低氧评估.
- 介绍放射学,机器学习和深度学习,用于定量特征提取.
- 讨论诸如成像标准化和数据可用性等挑战.
主要成果:
- 放射学使瘤缺氧的非侵入性定量评估成为可能.
- 机器和深度学习增强特征提取,以改善缺氧可视化.
- 整合多种omics显示了个性化癌症治疗的潜力.
结论:
- 放射学是诊断和管理缺氧瘤的一个有前途的工具.
- 克服标准化和数据可用性的挑战对于临床采用至关重要.
- 未来的整合与多omics可以个性化癌症治疗缺氧条件.
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