通过N-氨林来功能化的多 (甲基) 网络
Anita Wysopal1, Maria Owińska1, Ewa Stodolak-Zych1
1Faculty of Materials Science and Ceramics, AGH University of Krakow, 30-059 Kraków, Poland.
开发了新的聚合物生物制剂,使用与N-allylaniline. functionalized的聚甲西洛 (PHMS). 这些材料显示出对细菌有前途的抗微生物活性,其有效性取决于它们的结构和修饰水平.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
背景情况:
- 病原体对抗微生物药物的耐药性需要新的生物杀菌材料.
- 具有生物杀伤性部分的聚合物,如氨基和基,提供了一个有希望的策略.
- 聚甲) (PHMS) 被探索为一种多功能聚合物骨干,用于开发新的生物制剂.
研究的目的:
- 合成和描述非多孔和多孔PHMS网络.
- 将这些网络与N-allylaniline (Naa) 进行后功能化,以引入生物杀菌性质.
- 评估改性聚合物的抗微生物活性对抗阳性和阴性细菌.
主要方法:
- 通过散装交叉连接制备无孔PHMS,通过高内部相乳液 (HIPE) 制备有孔的PHMS.
- 使用divinyldisiloxane (M2Vi) 或tetravinyltetrasiloxane (D4Vi) 的交叉链接.
- 用N-艾利拉尼林 (Naa) 进行后功能化,并随后对氨基组进行四级化.
主要成果:
- 成功合成了具有明显微观结构的无孔和多孔PHMS网络.
- 由于Si-H含量更高,在无孔的网络中,N-阿利兰林的功能化更有效.
- 观察到对*S. aureus*和*E. coli*的抗菌活性,与功能化程度,交叉链接和微观结构相关.
结论:
- 基于PHMS的聚合物可以有效地功能化,以创建新的生物杀菌材料.
- 材料微观结构和功能化策略显著影响抗微生物药物的疗效.
- 这些发现支持开发先进的聚合物生物杀菌剂来对抗抗菌素耐药性.
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