衰老和胰岛素抵抗对老鼠骨肌肉功能和结构的性别依赖性影响
Patricia Sosa1,2,3, Javier Angulo2,4, Alberto Sánchez-Ferrer1,3
1Fundación para la Investigación Biomédica del Hospital de Getafe, 28905 Getafe, Spain.
International journal of molecular sciences
|July 29, 2025
概括
衰老和胰岛素抵抗 (IR) 损害了骨肌肉功能. 观察到性别特异性差异,结合衰老和IR对雌性大鼠的肌肉产生负面影响,比雄性大鼠更严重.
科学领域:
- 生理学 生理学 生理学
- 老年学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 骨肌的功能对于老年人的移动性和独立性至关重要.
- 衰老和胰岛素抵抗 (IR) 是导致功能衰退的关键因素.
- 基于性别的生物学差异可能会调节衰老和IR对肌肉的影响.
研究的目的:
- 调查衰老和IR对骨肌肉结构和功能的独立和联合影响.
- 在雄性和雌性大鼠中研究这些效应,重点关注延伸长肌 (EDL) 和肌肉.
主要方法:
- 使用了成年 (3个月) 和老年 (20个月) 的雄性和雌性大鼠.
- 在饮用水中使用8周20%果糖诱导胰岛素耐药性.
- 分析了肌肉收缩性,组织学和荷尔蒙水平.
主要成果:
- 老龄化减少了男性的肌肉力量,质量和丸激素;年轻男性的红外功能受损.
- 在女性中,衰老导致肌肉损失,而联合衰老-IR减少了收缩和损失加剧,降低了雌激素.
- 两种性别都经历了与衰老相关的糖溶性纤维损失和纤维化增加;IR影响了年轻动物的纤维和雄性纤维化.
结论:
- 老化和IR对骨肌的功能和结构产生性别特异性的影响.
- 了解这些差异对于开发针对年龄和IR相关肌肉功能障碍的有针对性的干预措施至关重要.
更多相关视频
08:22Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
Published on: March 20, 2017
8.8K
06:59A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
Published on: April 28, 2022
3.8K
相关概念视频
01:19The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K