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探索肠道微生物群和激素受体阳性乳腺癌中美拉能途径之间的相互作用

Aurora Laborda-Illanes¹, Soukaina Boutriq¹, Lucía Aranega-Martín¹

¹Medical Oncology Clinical Management Unit, Virgen de la Victoria University Hospital, Málaga Biomedical Research Institute (IBIMA) BIONAND Platform-CIMES-UMA, 29010 Malaga, Spain.

International journal of molecular sciences

|July 29, 2025

概括

改变的肠道细菌和破坏的黑激素合成与激素受体阳性乳腺癌 (BC) 有关. 在BC患者中观察到肠道透性增加和较高的NAS / 黑激素比率,这表明潜在的生物标志物.

科学领域:

微生物学微生物学
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

新出现的证据表明肠道微生物群,黑激素和激素受体阳性乳腺癌 (HR+BC) 之间存在联系.
肠道失调,黑激素合成和癌症发展之间的相互作用需要进一步研究.

研究的目的:

与对照组相比,研究肠道微生物群的变化,血清素-N-乙血清素 (NAS) - 黑激素轴,便代谢物和HR+BC患者的肠道透性.
探索肠道微生物群组成和测量的生物化学标志物之间的潜在相关性.

主要方法:

使用16S rRNA测序对肠道微生物群组成的分析.
通过质谱测量量血清素,NAS,黑激素和短链脂肪酸 (SCFA) 的量化.
使用ELISA和度测定测量β-葡萄糖酶 (βGD) 活性,素和氨酸合成酶 (AANAT,ASMT) 的测量.

主要成果:

HR+BC患者表现出肠道失调, *Bifidobacterium longum* 减少, *Bacteroides eggerthii* 增加.
在BC患者中,便βGD活性升高,SCFA水平和血清佐努林表明肠道透性增加.
BC患者血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清.

结论:

肠道微生物群的变化,乱的黑激素合成和增加的肠道透性可能导致HR+BC病理生理学.
*Bifidobacterium longum*与βGD活性呈负相关性,而*Bacteroides eggerthii*与βGD活性呈正相关性.
该NAS/黑激素比率可以作为HR+BC的潜在生物标志物,需要进一步的机制研究.

关键词:

在SCFAs中,SCFAs是最重要的.贝塔-葡萄糖酶的活性这种疾病叫做dysbiosis.我们的肠道微生物群.激素受体阳性的乳腺癌梅拉托尼基通路是什么意思透性透性的血清素-纳斯-黑素轴

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