潜在的miRNAs作为诊断生物标志物,以区分性结肠炎的疾病状态:系统性审查
Atta Ullah Khan1, Pilar Chacon-Millan1, Paola Stiuso1
1Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Napoli, Italy.
International journal of molecular sciences
|July 29, 2025
概括
微RNAs (miRNAs) 显示出作为非侵入性生物标志物的承诺,用于区分活跃的性结肠炎 (UC) 与非活跃的疾病. 像miR-21这样的特定miRNA在活性UC中始终升高,这表明了改善诊断的潜力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,影响结肠健康和患者的生活质量.
- 目前的UC诊断,如结肠镜和C-反应蛋白,是侵入性的或缺乏特异性.
- 对于UC诊断和监测而言,非常需要非侵入性,高度特定的生物标志物.
研究的目的:
- 系统地审查microRNAs (miRNAs) 作为诊断生物标志物的潜力,以区分活性和非活性性结肠炎.
- 为了识别与非活性疾病相比,在活性UC中持续失调的特定miRNAs.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在选择相关研究时,采用了包含和排除的标准.
- 分析了7项研究,共有514名参与者 (181名UC活跃,116名UC不活跃).
主要成果:
- 多个miRNAs在活性和非活性UC之间显示出差异性表达.
- 在活跃的UC中,miR-21,miR-126,miR-146b-5p和miR-223均在持续上调.
- 这些已识别的miRNAs涉及与UC病变发生相关的炎症途径.
结论:
- 某些miRNA显示出作为UC疾病活动的非侵入性诊断生物标志物的潜力.
- 需要对更大的队列进行进一步的验证研究,以确认它们的临床实用性.
- miRNAs可以促进非侵入性监测,并为UC管理中的治疗决策提供信息.
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