在纤维性疾病和癌症中使用安菲瑞古林
Tae Rim Kim1, Beomseok Son1, Chun Geun Lee2
1siRNAgen Therapeutics, Daejeon 34302, Republic of Korea.
International journal of molecular sciences
|July 29, 2025
概括
安菲瑞古林 (AREG) 通过持续的表皮生长因子受体 (EGFR) 信号驱动纤维化. 针对AREG提供了一种对抗纤维化和恶性疾病的双重战略,精准医学方法显示出有前途.
科学领域:
- 纤维化研究纤维化.
- 癌症生物学 癌症生物学
- 分子信号通道的分子信号通道.
背景情况:
- 纤维化疾病是全球主要的健康挑战,治疗选择有限.
- 红素 (AREG),一种表皮生长因子受体 (EGFR) 连接体,通过持续信号传递在纤维生成中发挥着关键作用.
- AREG表达与多个器官的疾病严重程度有关,并与癌症共享机制.
研究的目的:
- 审查安菲瑞古林 (AREG) 的生物功能.
- 评估针对纤维化和恶性疾病的AREG治疗潜力.
- 强调AREG作为精准医学的潜在目标.
主要方法:
- 关于安菲瑞古林 (AREG) 和其在纤维化和癌症中的作用的研究文献综述.
- 分析涉及AREG和EGFR的信号通路.
- 对AREG向疗法的临床前和临床数据的检查.
主要成果:
- 通过持续的EGFR信号传递和TGF-β激活,AREG调解纤维化.
- 升高的AREG水平与各种器官中纤维化疾病的严重程度相关.
- 向AREG显示了抗纤维和抗癌作用,提高了化疗的疗效.
- 像SAMIRNA-AREG这样的新疗法在早期试验中显示出特异性和安全性.
结论:
- AREG是纤维化的关键调解者,也是纤维化疾病的潜在治疗点.
- 向AREG为治疗纤维化和癌症提供了一种双重效益的策略.
- 针对AREG的个性化医疗方法有望改善纤维化和恶性疾病的临床结果.
关键词:
欧洲农业基准基金 (EGFR) 信号发送.这就是SAMIRNA.在TGF-β的基础上.氨基氨酸 (Amphiregulin) 是一种氨基氨酸.癌症 癌症 癌症 癌症 癌症纤维化 纤维化整合物是一种整合物.肌纤维母细胞细胞.更多相关视频
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
10.5K
07:21Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
Published on: December 26, 2019
7.6K
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
02:38Mitogens and the Cell Cycle
6.9K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.9K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
01:16TGF - β Signaling Pathway
7.7K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.7K
01:17Intracellular Signaling Affects Focal Adhesions
2.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.8K