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纳米二氧化诱导小鼠的卵巢功能损伤通过调解粒状细胞的亡

Jie Chen^1,2, Yaxuan Zhang¹, Shengbo Zhang¹

¹School of Life Science, Inner Mongolia University, Hohhot 010000, China.

International journal of molecular sciences

|July 29, 2025

概括

暴露于纳米二氧化 (nano-TiO2) 伤害女性卵巢,造成氧化应激和破坏生殖基因. 这种纳米粒子积累以剂量依赖的方式降低了生育能力和卵巢功能.

科学领域:

生殖毒理学生殖毒理学
纳米材料的安全性
环境健康环境健康

背景情况:

纳米粒子 (NP) 在女性身体中的积累引起了对生殖健康的担忧.
纳米二氧化 (nano-TiO2) 是一种常见的纳米材料,具有潜在的毒理学影响.

研究的目的:

调查纳米-TiO2对卵巢的毒性影响,并阐明潜在的机制.
评估不同纳米TiO2度对女性生殖内分泌功能的影响.

主要方法:

在小鼠中建立了纳米TiO2积累模型.
对垃圾排放率,性激素水平和卵巢指数的评估影响.
研究的机制包括反应性氧物种 (ROS) 生产,线粒体膜潜力和基因表达.

主要成果:

纳米TiO2暴露显著降低了垃圾排放率,性激素水平和卵巢指数,以剂量依赖的方式.
纳米-TiO2诱导过度的ROS产量,导致线粒体功能障碍和增加颗粒细胞亡.
抑制了卵巢特异性和颗粒细胞功能基因的表达.

结论:

纳米TiO2对卵巢形态和功能通过颗粒细胞中的氧化应激产生"双重打击".
细胞平衡的破坏和对生殖基因网络的干扰有助于卵巢功能下降.
为评估女性纳米材料的生殖风险提供了证据.

关键词:

这就是ROSOS ROS.灭症 (apoptosis) 是一种死亡的过程.细胞颗粒状颗粒素的细胞.纳米-TiO2 的二氧化碳.卵巢卵巢是一个卵巢.

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