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利用植物性纳米颗粒用于向治疗:一种绿色方法来治疗癌症和细菌感染
Mirela Claudia Rîmbu1,2, Daniel Cord1,2, Mihaela Savin3
1Pharmacy Faculty, "Titu Maiorescu" University, 040314 Bucharest, Romania.
International journal of molecular sciences
|July 29, 2025
概括
这项研究探讨了用于绿色纳米粒子合成的植物提取物,发现花和甜蜜木金和银纳米粒子对细菌和癌细胞有效,具有潜在的治疗应用.
科学领域:
- 纳米粒子的绿色合成
- 植物化学 植物化学
- 纳米医学是一种纳米医学.
背景情况:
- 植物提取物具有具有治疗潜力的生物活性化合物.
- 纳米粒子在医学和材料科学中提供了新的应用.
- 绿色合成为传统纳米粒子生产提供了一个环保的替代方案.
研究的目的:
- 研究Taraxacum officinale () 和Artemisia annua (甜蜜) 提取物的抗氧化,抗微生物和抗瘤活性.
- 探索这些植物提取物在金纳米粒子 (AuNPs) 和银纳米粒子 (AgNPs) 的绿色合成中的作用.
- 描述合成的纳米粒子,并评估它们的生物活动和细胞毒性.
主要方法:
- 绿色合成AuNP和AgNP使用水和乙醇植物提取物.
- 使用UV-Vis,光谱学,SEM,DLS,HRTEM和泽塔电位分析对纳米粒子进行全面的表征.
- 对黄金葡萄球菌和大肠杆菌的抗微生物活性评估,以及对LoVo和MDA-MB-231癌细胞系的细胞毒性测定.
主要成果:
- 观察到纳米粒子大小和稳定性的溶剂依赖的变化.
- 来自花的金纳米颗粒显示出强烈的抗菌活性,可以对抗S. aureus.
- 这两种植物的银纳米颗粒对大肠杆菌有效.
- 生物的银和金纳米颗粒证明了癌细胞活力的显著降低,具有有利的选择性指数.
结论:
- 在绿色纳米粒子合成过程中,Taraxacum officinale和Artemisia annua提取物是有效的药物.
- 合成的AuNP和AgNP表现出有前途的抗微生物和抗瘤活性.
- 生物纳米颗粒显示出治疗应用的潜力,需要进一步的体内研究.
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