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居住在城市或农村地区的患者之间乳腺瘤生物组的组成和功能差异

Fazia Ait Zenati¹, Simone Baldi², Leandro Di Gloria³

¹Laboratory of Microbial Ecology, Department of Microbiology, University of Bejaia, Bejaia 06000, Algeria.

|July 29, 2025

概括

城市和农村环境塑造了乳腺癌微生物组 (oncobiome). 农村患者表现出明显的细菌组成和增加的脂生物合成途径,这表明环境对乳腺癌发展的影响.

科学领域:

微生物学微生物学
在瘤学瘤学.
环境健康环境健康

背景情况:

乳腺癌 (BC) 是妇女死亡的主要原因.
人们越来越认识到乳腺微生物群在乳腺癌发生中的作用.
环境和社会经济因素影响BC流行和瘤相关细菌.

研究的目的:

分析癌症 (瘤生物体) 和相邻的健康乳腺癌组织中的乳腺微生物群的组成和功能特征.
为了比较来自城市和农村地区的患者的瘤生物组.
调查环境因素对乳腺生态系统的影响.

主要方法:

使用16S rRNA测序来分析微生物群的组成.
通过对未观察到状态的重建对社区的族群遗传学研究 (PICRUSt2) 用于功能分析.
在城市和农村患者队列之间进行了比较分析.

主要成果:

在城市和农村的BC患者之间发现了乳腺瘤生物组合的显著差异.
特定的细菌属 (Selenomonas,Centipeda,Leptotrichia,Neisseria,Porphyromonas) 和家族 (Neisseriaceae,Porphyromonadaceae,Selenomonadaceae) 在农村患者的生物组中得到了丰富.
与城市患者相比,农村患者的瘤生物组中观察到脂生物合成途径的增加.

结论:

在城市和农村BC患者之间的乳腺瘤生物组中存在明显的组成和功能差异.
环境因素似乎影响了乳腺微生物群的组成.
这些微生物组的变化可能在乳腺癌的发展和/或进展中发挥作用.

关键词:

16S 测序是指 16S 的测序.乳腺癌乳腺癌乳腺癌乳腺的微生物群.生活区生活区生活区在cobiome上

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