狼抗凝剂测试用于诊断抗脂综合征:由当地实践提供信息的观点
Emmanuel J Favaloro1,2,3,4, Leonardo Pasalic1,2,5
1Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW 2145, Australia.
Journal of clinical medicine
|July 29, 2025
概括
狼抗凝剂 (LA) 测试对于诊断抗脂综合征 (APS) 是至关重要的. 本综述解决了LA检测方面的挑战,特别是直接口服抗凝剂 (DOAC),以提高诊断准确性.
科学领域:
- 血液学 血液学 血液学
- 临床化学 临床化学
- 免疫学 免疫学 免疫学
背景情况:
- 狼抗凝剂 (LA) 是诊断抗脂综合征 (APS) 的一个关键实验室标准.
- 目前的指导方针建议使用至少两种不同的测试来检测LA,通常偏好激活的部分血栓形成时间 (aPTT) 和稀释的拉塞尔蛇毒毒时间 (dRVVT).
- 由于越来越多地使用直接口服抗凝剂 (DOAC),由于潜在的假阳性结果,LA测试面临挑战.
研究的目的:
- 提供最新的狼抗凝剂 (LA) 测试方法.
- 审查当前关于LA检测的文献和当地实践.
- 帮助实验室解释LA结果以诊断或排除抗脂综合征 (APS).
主要方法:
- 关于狼抗凝剂 (LA) 测试的最新科学文献的综述.
- 对LA评估的当地实验室实践的分析.
- 对LA检测的不同测试原理的比较.
主要成果:
- 激活的部分血栓形成时间 (aPTT) 和稀释的拉塞尔蛇毒毒时间 (dRVVT) 通常是LA测试的首选方法.
- 对LA检测的测试对各种抗凝剂可能敏感,可能导致错误的阳性结果.
- 直接口服抗凝剂 (DOAC) 复杂化了LA的解释.
结论:
- 精确的狼抗凝剂 (LA) 测试对于诊断抗脂综合征 (APS) 是必不可少的.
- 需要仔细解释LA结果,特别是在使用直接口服抗凝剂 (DOAC) 的患者中.
- 本综述提供了改善临床实践中LA测试和解释的见解.
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