转换为阿弗利塞普特8毫克治疗神经血管与年龄相关的黄斑退化后的初始反应
Chikako Hara1, Satoko Fujimoto1, Yoko Fukushima1,2
1Department of Ophthalmology, Graduate School of Medicine, University of Osaka, Osaka 565-0871, Japan.
Journal of clinical medicine
|July 29, 2025
概括
转换为aflibercept 8 mg用于新血管与年龄相关的黄斑变性 (nAMD) 显示了最初的成功. 在大约一半的患者中,子视网膜液和视网膜内液溶解,没有观察到任何不良影响.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理干预药理干预
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 需要持续的抗血管内皮生长因子 (VEGF) 治疗.
- 切换抗VEGF治疗是一种管理nAMD的常见策略.
- 阿弗利伯塞普特8毫克是一种用于治疗nAMD的新配方.
研究的目的:
- 在nAMD患者中,评估转换为aflibercept 8 mg的初始解剖和功能结果.
- 评估aflibercept 8 mg在消除排泄性变化的有效性 (视网膜下液,视网膜内液,血清色素上皮质脱落).
- 为了确定阿弗利伯塞普特8毫克是否维持或改善nAMD患者的视力敏度.
主要方法:
- 追溯分析了来自98名nAMD患者的102只眼睛,这些患者已转换为aflibercept 8mg.
- 纳入标准:排泄性变化的存在和转换前后稳定的剂量间隔.
- 在切换前后评估最佳校正的视力敏度 (BCVA) 和中央叶厚度 (CFT).
主要成果:
- 中部骨厚度 (CFT) 从272 ± 85μm显著减少到246 ± 79μm (p < 0.0001).
- 最好的校正视敏度 (BCVA) 保持稳定.
- 下腺液 (SRF) 和内腺液 (IRF) 的完全解脱分别发生在44%和55%的眼睛中;血清色素上皮质脱落 (sPED) 在29%的眼睛中消失.
- 没有报告眼部或全身不良事件.
结论:
- 转换为aflibercept 8 mg在nAMD患者中显示出有希望的初始解剖结果.
- 在现实世界中,Aflibercept 8 mg有效地减少了视网膜液和PED.
- 治疗耐受性很好,没有观察到任何不良影响.
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