焦虑和抑郁症状COVID-19后大流行在固体器官移植接受者身上出现:加拿大重复跨部门研究
Jad Fadlallah1, Vishva Shah1, Ana Samudio1
1Ajmera Transplant Center, Division of Nephrology, University Health Network, Toronto, ON M5G 2N2, Canada.
Journal of clinical medicine
|July 29, 2025
概括
在COVID-19大流行开始后移植的固体器官移植接受者报告了增加的焦虑症状. 与大流行前水平相比,抑郁症症状没有变化,这凸显了在传染病危机期间需要心理健康支持的需要.
科学领域:
- 医学研究 医学研究
- 精神病学是一个精神病学.
- 移植医学 移植医学
背景情况:
- 固体器官移植接受者 (SOTRs) 面临更高的COVID-19严重结局的风险.
- 感染风险可以使SOTRs的焦虑和抑郁症状恶化.
- 评估SOTRs因疫情而发生的心理健康变化至关重要.
研究的目的:
- 为了比较COVID-19大流行开始前和之后的SOTR中的焦虑和抑郁症状.
- 用PROMIS分数来评估大流行对SOTRs心理健康的影响.
主要方法:
- 从2016-2024年间成年SOTR (脏,脏-胰腺,肝脏) 的横截面数据的二次分析.
- 参与者被分类为流行前 (PRE),移植流行前但被评估流行后 (POST-1),移植和评估流行后 (POST-2).
- 利用多变量线性回归来比较患者报告结果测量信息系统 (PROMIS) 焦虑 (A) 和抑郁 (D) 在不同组的得分.
主要成果:
- 与PRE组相比,POST-2组显示出明显更高的PROMIS-A得分 (表明更严重的焦虑) (p=0.02).
- 与PRE (或1.59) 相比,在POST-2组中,更高比例的患者有潜在的临床显著焦虑.
- 在暴露组中没有观察到PROMIS-D得分的显著差异.
结论:
- 在大流行开始后接受移植的SOTRs经历了增加的焦虑症状.
- 在大流行前和大流行后的移植组中,抑郁症症状水平保持相似.
- 需要进一步的研究,以解决在传染病危机期间为SOTRs提供心理健康支持的问题.
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