癌症免疫治疗中的静脉血栓栓塞事件:叙述性审查
Cosmo Fowler1, Stephen M Pastores2,3
1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Journal of clinical medicine
|July 29, 2025
概括
癌症免疫疗法,如免疫检查点抑制剂 (ICI),通过不同的炎症途径增加静脉血栓栓塞 (VTE) 风险. 这些不断发展的治疗方法需要新的风险模型和量身定制的预防策略.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症治疗的一个严重并发症.
- 免疫疗法相关的VTE可能与化疗相关的VTE有不同的原因.
研究的目的:
- 在接受免疫治疗的癌症患者中审查VTE的流行病学和病原性.
- 发现当前风险评估中的差距,并建议未来的研究方向.
主要方法:
- 对现实世界研究和现有文献进行叙述性审查.
- 检查免疫检查点抑制剂 (ICI),CAR T细胞疗法和双特异性T细胞参与剂 (BiTEs) 患者的VTE发生率和机制.
主要成果:
- 在ICI接受者中,VTE的发病率差异很大,可能与白血素-8和中性粒细胞外细胞陷有关.
- 由于细胞因子释放综合征,CAR T细胞疗法存在独特的风险.
- 现有的VTE风险工具在免疫治疗患者的预测价值有限.
结论:
- 了解免疫疗法特异性静脉瘤机制至关重要.
- 新的风险分层模型和定制的血栓预防策略是必不可少的.
- 需要进一步的研究来优化癌症免疫治疗患者的结果.
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