个人结肠片段组织学活动对性结肠炎患者疾病复发的影响
Steven Li Fraine1, Victoria Marcus2, Chelsea Maedler Kron2
1Inflammatory Bowel Disease Centre, Division of Gastroenterology and Hepatology, McGill University Health Centre (MUHC), Montreal, QC H4A-3J1, Canada.
结肠部分的组织学活性不能预测性结肠炎复发. 即使有多段缓解期,性结肠炎患者的疾病复发仍然无法预测.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床病理学 临床病理学
背景情况:
- 性结肠炎 (UC) 管理依赖于实现和维持缓解.
- 组织学评估越来越多地用于评估UC活动.
- 预测UC患者的疾病复发对于个性化治疗至关重要.
研究的目的:
- 评估UC复发的个体结肠段组织学活动的预测值.
- 为了确定组织学缓解中的结肠细分数是否影响复发风险.
主要方法:
- 对253名UC患者临床缓解期的前性观察性研究.
- 来自多个细分段的结肠活检评估了使用吉博斯 (GB) 评分的组织学活性.
- 患者在12个月内监测疾病复发.
主要成果:
- 19%的患者在12个月内出现了疾病复发.
- 在任何结肠部分 (直肠,西格,下降,横向,右结肠) 的组织学活性 (GB ≥ 3.1) 并没有预测复发.
- 在单个细分或多个细分的组织学缓解 (GB ≤ 2.0) 并不能预测持续缓解.
结论:
- 个人结肠部分的组织学活性不是性结肠炎复发的可靠预测指标.
- 实现组织学缓解的结肠细分数不会影响疾病复发的风险.
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