瘤中巨细胞的PET和SPECT成像:最新情况
Shaobo Li1,2, Alex Maes3,4, Tijl Vermassen2,5,6
1Department of Diagnostic Sciences, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Journal of clinical medicine
|July 29, 2025
概括
使用PET和SPECT的非侵入性成像可以通过向生物标志物来追踪与瘤相关的巨细胞 (TAM). 针对TAM的探针的进展显示了瘤免疫监测和治疗的前景,有助于个性化医疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 医疗成像医学成像
背景情况:
- 瘤相关巨细胞 (TAMs) 是影响瘤进展和治疗结果的关键免疫细胞.
- 传统的TAM检测方法,如活检是侵入性的,缺乏全身动态监测能力.
- 阳位子发射断层扫描 (PET) 和单光子发射计算机断层扫描 (SPECT) 提供了非侵入性成像替代方案.
研究的目的:
- 审查用于非侵入性瘤免疫监测的TAM准成像探针的进展.
- 评估这些探针在瘤向和治疗应用中的潜力.
- 以突出挑战和未来的方向在TAM准成像精准医学.
主要方法:
- 关于TAM准成像探头的文献综合审查.
- 针对细胞表面标记物 (例如CD206),代谢/功能标记物 (例如TSPO,CCR2) 和多功能纳米探针的探针分析.
- 在临床前和早期临床研究中评估治疗潜力.
主要成果:
- 各种TAM特定的生物标志物 (CD206,TSPO,CCR2) 被先进的成像探针所准.
- 像Ga-NOTA-anti-CD206和Cu-Macrin这样的探测器显示出高的特异性和治疗潜力.
- 挑战包括目标异质性,非目标效应和临床翻译障碍.
结论:
- 针对TAM的成像提供了一种非侵入性的方法来监测瘤免疫力和指导治疗.
- 进一步开发多目标探头和多式成像技术对于临床转化至关重要.
- 优化的TAM成像将增强精准医学和个性化癌症治疗策略.
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