在使用卡伯戈林后,在非功能性PitNET中发生下垂体中风:病例报告和文献综述
Federica De Luca1, Margherita Paccagnella1, Anna Pizzo1
1Department of Medical Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, 34149 Trieste, Italy.
Journal of clinical medicine
|July 29, 2025
概括
下垂体中风 (PA) 是一种罕见的紧急情况. 多巴胺激动剂,如卡伯戈林,可以治疗垂体瘤,但可能触发PA,特别是在非功能瘤. 建议对患有大型瘤的患者进行密切监测.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 在瘤学瘤学.
背景情况:
- 垂体中风 (PA) 是一种罕见的,急性疾病,涉及垂体腺出血或心脏病发作.
- 多巴胺激动剂 (DAs) 用于 pituitary神经内分泌瘤 (PitNETs),特别是前列腺瘤.
- 通过使用DA,PA可以沉,尽管通常与分泌PitNETs有关.
研究的目的:
- 报告患有非功能性PitNET,接受卡伯戈林治疗的患者患有PA的病例.
- 审查与DA使用相关的PA文献.
- 调查卡伯戈林和PA在非功能PitNET中的潜在联系.
主要方法:
- 关于与DA使用相关的PA病例的文献综述 (PubMed搜索到2025年3月).
- 一个在卡伯戈林治疗中具有非功能PitNET的患者的PA病例报告.
- 对瘤特征和治疗结果的分析.
主要成果:
- 在文献中,共有43个与DA使用相关的PA病例被确定,所有病例都涉及分泌PitNETs (86%的PRL分泌).
- 在卡伯戈林治疗期间,一个患有不起作用的PitNET的患者发生了一种新的PA病例.
- 报告的病例被保守地管理,内分泌功能自发恢复.
结论:
- 卡伯戈林在缩小表达多巴胺2受体的非功能PitNET方面表现出有效性.
- 这一案例凸显了卡伯戈林治疗的潜在并发症,即PA,即使在非功能性PitNET中也是如此.
- 患有非功能性PitNETs的患者,特别是患有大型瘤的患者,在DA治疗期间需要对PA进行警监测.
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