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在低心血管风险的个体中肠道微生物群的元基因组特性
Argul Issilbayeva1,2, Samat Kozhakhmetov1, Zharkyn Jarmukhanov1
1National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Astana 010000, Kazakhstan.
Journal of clinical medicine
|July 29, 2025
概括
低心血管风险个体的肠道微生物群差异可能表明早期疾病转移. 像Faecalibacterium prausnitzii和Fusicatenibacter saccharivorans这样的特定细菌显示出与脂质标记物的相反联系,这表明它们可能在代谢健康中发挥作用.
科学领域:
- 微生物组研究的研究.
- 心血管疾病是什么心血管疾病
- 代谢健康 代谢健康
背景情况:
- 心血管疾病是全球主要的死亡原因.
- 肠道微生物组越来越被认为是心血管健康的关键因素.
- 早期发现疾病转移对于干预至关重要.
研究的目的:
- 在低心血管风险 (LCR) 个体中描述肠道微生物组合和代谢途径.
- 将LCR个体与健康对照进行比较,以识别心血管疾病的早期迹象.
- 探索肠道细菌和心血管风险标志物之间的关系.
主要方法:
- 来自25名LCR个体和25名匹配的健康对照体的便样本的枪支元基因组测序.
- 对所有参与者进行全面的心血管评估.
- 使用MetaPhlAn 4和HUMAnN 3进行分类学和功能分析.
主要成果:
- 在LCR和对照组之间发现了肠道细菌社区结构的显著差异.
- 在LCR个体中丰富Faecalibacterium prausnitzii,与ApoB.负相关.
- *Fusicatenibacter saccharivorans*与ApoB正相关;在LCR组观察到改变的核酸生物合成和糖解途径.
结论:
- 在LCR个体中,肠道微生物群的明显特征可能表明早期心血管疾病的发展.
- *F. prausnitzii*和*F. saccharivorans*与脂质参数的对立相关性表明它们在心脏代谢健康中的作用.
- 肠道微生物组的特征可以作为心血管疾病之前代谢失调的早期指标.
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