相关实验视频

Updated: Sep 13, 2025

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

Published on: April 21, 2015

探讨马黄抗流感的分子机制:一个集成的计算和实验研究

Jun Qin¹, Fang Xiang¹, Yanqing Wang²

¹Pharmacy Department, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

|July 29, 2025

概括

马黄开 (MHD) 通过向AKT1,EGFR和SRC,显示出抗H1N1病毒活性. 凯姆菲罗尔,奎尔塞丁和卢特奥林等关键化合物有助于其在治疗流感时的抗病毒和抗炎作用.

科学领域:

传统中国医药传统中国医药
药理学药理学是指药理学的学科.
病毒学病毒学

背景情况:

马黄开 (MHD) 在临床上用于病毒感冒和肌肉疼痛.
它对流感和抗炎机制的有效性需要阐明.

研究的目的:

为了研究马黄 (MHD) 对流感的治疗效果.
在流感治疗中识别MHD的活性成分,分子标和机制.

主要方法:

网络药理学用于识别核心标 (AKT1,EGFR,SRC) 和化合物 (kaempferol,quercetin,luteolin).
基因本体学和KEGG丰富分析.
分子对接和体外验证 (细胞病变效应测定,RT-PCR).

主要成果:

MHD表现出抗H1N1病毒活性.
关键化合物凯姆菲罗尔,奎尔丁和黄素向AKT1,EGFR和SRC.
机制包括抗病毒,抗炎和免疫调节途径.

结论:

MHD具有抗H1N1活动.
这项研究阐明了MHD的活性成分,点和流感机制.
为进一步研究MHD的保护性和抗炎作用提供了基础.

关键词:

马黄的蒸煮剂马黄的蒸煮剂这是RT-PCR.细胞实验细胞实验流感流感流感流感流感分子对接的分子对接.网络药理学网络药理学

更多相关视频

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

相关概念视频

Leaky Scanning

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...