前皮质脂肪厚度作为代谢相关性肝病的潜在非侵入性标记:一项回顾性研究
1Department of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.
Medicine
|July 29, 2025
概括
通过超声波测量最大腹前脂肪厚度 (PMFT) 和腹部脂肪指数 (AFI) 是有效的,用于诊断代谢功能障碍相关脂肪性肝病 (MASLD) 的非侵入性标记. PMFT表现出最强的关联性和诊断准确性,支持其用于早期MASLD检测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 放射学 放射学是一门学科.
- 内部医学 内部医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率正在上升,内脏脂肪是关键因素.
- 超声波测量最大腹前脂肪厚度 (PMFT) 和腹部脂肪指数 (AFI) 是内脏脂肪区域的成本有效替代品.
- 由于MASLD的发病率日益增加,非侵入性评估至关重要.
研究的目的:
- 使用超声波调查MASLD和PMFT之间的关联.
- 评估PMFT和AFI在识别MASLD的诊断性能.
- 为了比较PMFT,AFI和最小皮下脂肪厚度 (SMFT) 在MASLD诊断中的实用性.
主要方法:
- 对130名被评估为MASLD的患者进行了回顾性研究.
- 在MASLD和非MASLD组之间比较了PMFT,AFI和SMFT的超声波测量.
- 使用二进制物流回归和ROC分析来评估诊断准确性.
主要成果:
- MASLD与PMFT有很强的关联 (OR=33.626) 并与AFI独立相关 (OR=3.492).
- PMFT显示了高的诊断准确性 (AUC,P<.001) 与一个切断>15.9毫米.
- 此外,AFI也显示出显著的诊断值 (AUC,P<.01),截止值>1.18,而SMFT缺乏诊断相关性.
结论:
- PMFT和AFI是用于MASLD诊断和风险评估的有价值的非侵入性超声波标记.
- PMFT是最强烈的相关标志物,突出其早期MASLD检测的潜力.
- SMFT不是MASLD的相关诊断指标.
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