相关实验视频
Updated: Sep 13, 2025

09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
2.9K
文拉法辛诱导的血小板缺血:一个病例报告和文献综述
Shi Lijun1, Ma Zhongrui2,3, Wei Li1
1Department of Hematology, Chengdu Fifth People's Hospital, Chengdu, China.
Medicine
|July 29, 2025
概括
作为抗抑郁药的文拉法辛化,很少会导致药物诱导的血小板缺血 (DITP),这是一种血小板低的情况. 及时停止服用药物并开始治疗可以恢复正常的血小板数量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 药物诱导的血小板缩 (DITP) 是一种免疫媒介的不良药物反应.
- 虽然各种抗抑郁药物已与DITP有关,但很少报道因venlafaxine化引起的病例.
研究的目的:
- 报告一种罕见的严重血小板缩和皮下出血的罕见病例,该病例与芬拉法辛化相关.
- 强调在临床实践中考虑文拉法辛作为DITP的潜在原因的重要性.
主要方法:
- 一个案例记录了一名焦虑症患者在服用含有文拉法辛的治疗方案后出现严重的血小板缺血.
- 为了确认DITP,排除了对血小板缺血的其他次要原因.
- 治疗包括葡萄糖皮质类药物,复合人体血栓形成素和停止使用文拉法辛.
主要成果:
- 患者经历了严重的血小板缺血和皮下出血.
- 治疗后血小板数正常化和停止使用文拉法辛.
- 在三个月的随访中,血小板数量保持正常.
结论:
- 文拉法辛化是一种罕见但可能导致DITP的原因.
- 临床医生应对这种不良反应保持警,并告知患者.
- 早期戒毒和适当的治疗对于康复至关重要.
- 查BCR/ABL基因或PH染色体是推用于患有骨髓质疏松性瘤特征的患者,以排除慢性骨髓性白血病.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
37
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
37
Venous Thrombosis III: Interprofessional Care
22
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
Antidepressant Drugs: Overview
762
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
762
Electroconvulsive Therapy
190
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
190
Pharmacovigilance
996
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
996
Venous Thrombosis IV: Nursing Management
24
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
24

