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基于1,2,3-Triazoles的设计合成蒂亚佐利丁-2,4-二离子衍生物抗癌,抗微生物和分子对接研究

Kishan Chevula¹, Prasad Chennamsetti¹, Nalaparaju Nagaraju¹

¹Department of Chemistry, Osmania University, Hyderabad, India.

Chemistry & biodiversity

|July 29, 2025

概括

新的 thiazolidine-2,4-dione衍生物显示出作为抗癌和抗菌剂的前景. 微波合成为这些新型化合物提供了更高的产量和更短的反应时间.

科学领域:

药用化学医学化学
有机合成有机合成
药物发现药物发现药物发现

背景情况:

提阿佐利丁-2,4-二衍生物被认为具有多种生物活性.
开发新的抗癌和抗微生物药物是研究的一个关键领域.
有效的合成途径对于药物开发至关重要.

研究的目的:

设计和合成新型的 thiazolidine-2,4-dione衍生物.
评估它们作为抗癌和抗微生物药物的潜力.
通过分子对接来探索它们与多聚酶II的相互作用.

主要方法:

使用常规和微波辐射技术进行合成.
通过红外,NMR (1H, 13C),质谱和元素分析进行结构性表征.
对MCF-7细胞系进行抗癌活性评估;对细菌和真菌进行抗菌活性测试.
对Topoisomerase II进行的分子对接研究.

主要成果:

化合物6a和6h对MCF-7细胞表现出显著的抗癌活性 (IC50值为12.11 ± 2.9 μM和15.82 ± 10.1 μM).
化合物6k表现出强大的抗菌活性,而化合物6l表现出良好的抗真菌活性.
微波辐射方法导致了更高的产量,更短的反应时间和更简单的净化.

结论:

合成的 thiazolidine-2,4-dione 衍生物具有显著的抗癌和抗菌特性.
微波辅助合成为生产这些化合物提供了高效和有利的途径.
这些发现凸显了这些衍生品作为新治疗剂的潜在来源的潜力.

关键词:

这是一种抗癌药物.抗微生物药物是一种抗菌药物.分子对接的分子对接.提阿佐利丁-2,4-二衍生物

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