最近的萨尔科佩尼亚定义 - - 腹腔透析患者患病率和残疾关联的变化
Sasiwimon Meenetkum1,2, Sarinya Boongird2, Piyatida Chuengsaman3
1Department of Epidemiology, Faculty of Public Health, Mahidol University, Bangkok, Thailand.
Journal of cachexia, sarcopenia and muscle
|July 29, 2025
概括
在腹腔透析 (PD) 患者中,肉类是常见的,其患病率根据定义有很大差异. 低肌肉强度是萨尔科佩尼亚的一个组成部分,与PD中的功能限制和依赖有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年病的医生 老年病的医生
- 肌肉骨健康 肌肉骨健康
背景情况:
- 麻症在慢性病 (CKD) 中很普遍,但缺乏统一的诊断标准.
- 最近的定义,如 Sarcopenia Definitions and Outcomes Consortium (SDOC),专注于肌肉功能而不是质量.
- 这些新定义的实用性及其与末期病 (ESKD) 患者的功能残疾的联系在腹腔透析 (PD) 患者的实用性是不充分研究的.
研究的目的:
- 在泰国PD患者中使用各种定义来评估肉类的流行率和一致性.
- 评估这个人群中肉类症和功能限制之间的关联.
- 为了在PD的背景下比较较旧的和新的肉症诊断标准.
主要方法:
- 对384名泰国PD患者进行横截面研究,测量了完整的肉症 (BIA,手握强度,步行速度).
- 使用FNIH,IWGS,EWGSOP2,AWGS2019和SDOC定义进行分类的患者.
- 通过巴特尔日常生活活动 (ADL) 评分评估功能障碍;使用多变量逻辑回归分析依赖关系.
主要成果:
- 麻症的患病率有显著的变化 (8.3%的FNIH到44.5%的SDOC).
- 除了EWGSOP2和IWGS,定义之间的一致性基本上很差.
- 功能限制在肉患者 (IWGS除外) 中更常见. FNIH和SDOC的定义与依赖性有显著的关联.
- 低肌肉强度是普遍存在的 (58.6%) 并与更高的功能限制和依赖性相关.
结论:
- 在PD患者中 Sarcopenia 是常见的,在流行率和功能关联的定义中存在显著的变化.
- 低肌肉强度是PD患者功能障碍的关键指标.
- 虽然SDOC与功能缺陷有关,但它可能会在PD中过度诊断肉类;需要进一步的研究来确定该组临床相关的标准.
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