氧化铜纳米颗粒作为不同Pt(II) 药物的输送载体:实验和理论评估
Shahdan Abdelkareem1, Mayyada M H El-Sayed1, Nahed Yacoub1
1Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt. T.Shoeib@aucegypt.edu.
Journal of materials chemistry. B
|July 29, 2025
概括
铜氧化物纳米颗粒有效携带. 抗癌药物,特别是. 这项研究表明CuO纳米颗粒可以提高药物输送和癌症治疗的疗效.
科学领域:
- 纳米技术和材料科学 材料科学
- 药用化学 医学化学
- 计算化学计算化学
背景情况:
- (II) 复合物是重要的化疗剂,但有严重的副作用和不良的口服生物可用性.
- 目前的类药物输送方法面临着系统性毒性和胃肠道降解等挑战.
- 有针对性的输送系统对于提高基抗癌药物的有效性和安全性至关重要.
研究的目的:
- 评估铜(II) 氧化物纳米粒子 (CuO NPS) 作为 ((II) 抗癌药物的载体.
- 为了研究cisplatin,oxaliplatin和nedaplatin在CuO纳米颗粒上的加载效率和吸附行为.
- 使用实验和理论方法,比较CuO纳米颗粒与不同药物的性能.
主要方法:
- 实验性表征包括UV可见光谱,FTIR光谱,BET表面积分析和X射线衍射 (XRD).
- 在周期边界条件下 (PBC) 使用密度函数理论 (DFT) 进行理论计算.
- 对药物加载效率,捕获效率和吸附能力的评估.
主要成果:
- 紫外线光谱检测显示,西斯在CuO纳米颗粒上表现出最高的捕获效率 (52%) 和负载能力 (949 mg g-1).
- DFT模拟证实了Pt(II) 药物在CuO (111) 表面的有利吸附,其中西斯显示了最强的相互作用 (吸附能量为-3.0 eV).
- 实验和理论数据都表明,西斯与CuO纳米粒子之间具有强大的结合和有利的相互作用.
结论:
- 铜 (II) 氧化物纳米颗粒显示出作为 (II) 抗癌药物的有效载体的巨大潜力.
- 与氧化和尼达普拉丁相比,西斯与CuO纳米颗粒的结合亲和力和相互作用强度优越.
- 纳米颗粒为增强化学疗法剂的输送和治疗作用提供了一个有希望的策略.
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