可切除食道状细胞癌的新辅助疗法后的病理完整反应:内镜特征和含义
Peng Yuan1, Zongchao Liu2, Liang Dai3
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Endoscopy, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Endoscopy international open
|July 29, 2025
概括
内镜特征可以准确预测新辅助疗法后食道状细胞癌 (ESCC) 患者的病理完整反应 (pCR). 一个机器学习模型在预测pCR方面表现出高准确性,有助于治疗评估.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 食道状细胞癌 (ESCC) 的治疗反应至关重要.
- 评估新辅助疗法的有效性对于患者的治疗结果至关重要.
- 病理完整反应 (pCR) 是成功治疗的关键指标.
研究的目的:
- 在ESCC患者中确定可预测PCR的内镜特征.
- 开发和验证用于预测PCR的机器学习模型.
- 为了提高ESCC中新辅助治疗后的评估.
主要方法:
- 分析了220名ESCC患者的回顾性和前性队列.
- 在新辅助疗法后评估了七种内镜特征.
- 使用机器学习训练和验证了一种多变量逻辑回归模型.
主要成果:
- 预测模型实现了高准确性:96.43% (培训),93.48% (内部验证) 和96.77% (前性验证).
- 特定的内镜特征,如痕和IPCL B型是显著的预测因素.
- 该模型在不同的验证集中展示了强大的性能.
结论:
- 内镜特征是ESCC患者pCR的重要预测因素.
- 开发的预测模型显示高精度和临床实用性.
- 这种工具可以帮助评估ESCC新辅助疗法后的治疗反应.
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