患有2型糖尿病的年轻成人和中年患者的认知功能障碍的患病率和模式
Subhankar Chatterjee1, Rana Bhattacharjee1, Anirban Sinha1
1Department of Endocrinology and Metabolism, Medical College and Hospital, Kolkata, India.
Journal of family medicine and primary care
|July 29, 2025
概括
认知障碍在2型糖尿病 (T2D) 患者中很常见,影响了超过一半的研究对象. 早期认知评估对于管理糖尿病和预防并发症至关重要.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 二型糖尿病 (T2D) 显著增加了认知障碍的风险.
- 早期发现T2D认知衰退对于有效的糖尿病自我管理和并发症预防至关重要.
- 关于使用综合工具对印度T2D人口认知障碍评估的数据有限.
研究的目的:
- 估计印度东部年轻和中年T2D患者认知障碍的患病率和模式.
- 通过一系列全面的测试来评估认知功能.
- 在这个人口群体中确定与认知障碍相关的因素.
主要方法:
- 一项涉及125名孟加拉语T2D患者 (20-60岁) 的横截面观察研究.
- 使用临床痴呆症评分尺度,MMSE,MoCA和ACE-III进行认知评估.
- 统计分析包括奇平方,曼-惠特尼U,斯皮尔曼相关性和后勤回归 (P <0.05显著).
主要成果:
- 59.20%的T2D患者表现出基于ACE-III的认知障碍.
- 与对照组相比,T2D患者认知障碍的几率高3.72倍.
- 观察到记忆力,流性和视觉空间能力的显著损伤.
- 与损伤相关的因素包括女性性别,较低的教育/SES,较低的BMI,神经病变,甲状腺功能低下,焦虑和抑郁症.
结论:
- 认知障碍在东印度中年,受过教育的T2D个体中非常普遍.
- 这项研究是该地区首次使用本地验证的综合认知尺度.
- 应将常规认知查纳入糖尿病护理,解决可修改的风险因素.
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