QTc延长与肝功能测试和肝硬化患者并发症的关联:一项观察性研究
Rhythm Yogandh Relekar1, Priyavardhan Mishra1, Vishal Raghunath Gabale2
1DY Patil Deemed to be University School of Medicine, Navi Mumbai, Maharashtra, India.
Journal of family medicine and primary care
|July 29, 2025
概括
QTc延长是肝硬化患者常见的ECG异常,影响超过64%. 这种心脏问题与肝功能测试和常见的肝硬化并发症有显著的相关性.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 肝硬化心肌病是一种与肝硬化相关的心脏功能障碍.
- 心电图 (ECG) 异常很常见,通常没有明显的症状.
- 了解这些心电图变化对于患者管理至关重要.
研究的目的:
- 为了研究ECG变化,特别是QTc间隔,在肝硬化多种原因的患者.
- 为了将这些心电图发现与肝功能测试 (LFTs) 和肝硬化的临床并发症相关联.
主要方法:
- 一项涉及300名患有肝硬化各种病因的患者的研究 (例如,ALD,NASH,DCLD,AIH,HCC,Hep-B,威尔逊病).
- 评估QTc间隔和与LFT参数 (SGOT,SGPT,ALP,间接 bilirubin) 的相关性.
- QTc 间隔与肝硬化并发症的相关性,如门高血压,壮症和,以及儿童-普格类.
主要成果:
- 在194名 (64.66%) 患者中检测到延长的QTc间隔,最常见的是DCLD.
- 在延长的QTc和并发症 (门脉高血压,大,) 之间发现了显著的关联 (P < 0.001).
- QTc 间隔与查尔德-皮格等级和SGOT/SGPT水平 (P < 0.001) 有显著的相关性,但与ALP或间接胆红素无关.
结论:
- 延长的QTc间隔是肝硬化中流行的一种ECG异常.
- QT延长与肝酶升高和肝硬化并发症的存在显著相关.
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