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血液参数区分COVID-19后的情况与肌痛性脑筋炎/慢性疲劳综合征和纤维肌痛

Karen Giménez-Orenga¹, Justine Pierquin², Joanna Brunel²

¹Doctoral School, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.

Brain, behavior, & immunity - health

|July 29, 2025

概括

人体内源性逆转录病毒W ENV蛋白可能导致肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和纤维肌痛 (FM). 生物标志物分析为诊断COVID-19后的疾病和相关的慢性疾病提供了潜力.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
神经学神经学

背景情况:

后COVID-19条件,包括ME/CFS和FM,出现衰弱的疲劳,疼痛和认知功能障碍.
人体内源逆转录病毒W (HERV-W) ENV蛋白表达与病毒感染和COVID-19后的严重程度有关.
在大流行前的ME/CFS和FM中研究了HERV-W ENV的存在,这表明在这些慢性疾病中病毒的潜在作用.

研究的目的:

调查HERV-W ENV在流行前的ME/CFS和FM病例中的存在.
在COVID-19后的条件下分析免疫反应,包括抗体异型和细胞因子概况.
确定生物标志物,用于对有重叠症状的疾病进行差异诊断.

主要方法:

对抗SARS-CoV-2抗原的IgM,IgG,IgA和IgE抗体的测量.
细胞因子 (IL-6,IL-8,IL-10,IFNγ,TNFα) 和神经纤维光链 (NfL) 的量化.
分析与疲劳相关的血细胞标记物.

主要成果:

在大流行前的ME/CFS和FM病例中检测到HERV-W ENV.
特定的生物标志物在区分COVID-19后的条件中显示出100%的灵敏度和高达71.9%的特异性.
在检测到的标记物和患者症状之间发现的相关性.

结论:

HERV-W ENV可能与ME/CFS和FM的病原发生有关.
已识别的生物标志物为区分复杂的后病毒综合征提供了诊断工具.
研究结果表明,对于慢性疲劳和疼痛症状,可能是新的治疗点.

关键词:

细胞因子 (cytokines) 是一种细胞因子.纤维肌痛是一种纤维肌痛.这就是HERV-W-ENVV.免疫球蛋白是一种免疫球蛋白.长时间的COVID-19 肌痛性脑筋炎/慢性疲劳综合征后COVID-19状态的情况.这就是SARS-CoV-2病毒.血清学血清学是一门学科.

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