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高通量F NMR 基隆分析用于查和定向进化 imine 降解酶

Shucheng Song1, Chenyang Wang2, Wenjing Bao2

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

ACS central science
|July 29, 2025
PubMed
概括

我们开发了一种快速的F NMR检测法,用于分析生物催化剂中的奇拉分子. 这种高通量方法加速了用于合成重要的药物中间体的酶的选.

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Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.
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