抗脂综合征患者复发性血栓瘤的危险因素-单中心队列研究
Natali Karandyszowska1,2, Francesca Faustini3, Hevgin Alagündüz1
1Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
概括
血栓缩和慢性病是抗脂综合征 (APS) 中复发性血栓形成的关键危险因素. 优化抗凝血是防止这些危险事件的关键.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 类风湿病学 类风湿病学
背景情况:
- 复发性血栓形成是抗脂综合征 (APS) 患者的一个重大临床挑战.
- 由于APS的罕见性,对导致APS中复发性血栓事件的特定风险因素的数据有限.
研究的目的:
- 调查心血管 (CV) 和APS相关风险因素与复发性血栓形成之间的关联.
- 评估调整后的全球抗脂综合征评分 (aGAPSS) 在预测复发性血栓形成方面的有用性.
主要方法:
- 在卡罗林斯卡大学医院 (Karolinska University Hospital) 的250名APS患者进行了一项回顾性队列研究 (2014-2020年).
- 考克斯的比例危险模型和物流/波桑回归被用来分析风险因素和复发性血栓形成.
- 每位患者的多重血栓事件被纳入分析.
主要成果:
- 血栓缩显著增加了复发性血栓形成的风险 (HR 2.57).
- 慢性病 (CKD) 与复发的可能性增加有关 (OR 2.55).
- aGAPSS的每一个点的增加与复发性血栓形成的风险增加10%相关 (HR 1.10). 不足够的抗凝血是近25%的复发的触发因素.
结论:
- 血栓缩是APS中复发性血栓形成的主要风险因素之一.
- 慢性病需要在对APS患者的风险评估中更加关注.
- 虽然aGAPSS显示了相关性,但需要进一步评估;改善抗凝剂是减少复发的必要条件.
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