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天然活性植物代谢物:向AMPK信号通路,用于治疗与代谢功能障碍相关的脂肪肝疾病

Hualing Wang¹, Xinyu Liu¹, Chunyi Wang¹

¹Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in pharmacology

|July 29, 2025

概括

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题. 本综述探讨了针对AMPK途径的天然植物化合物,为MAFLD提供了潜在的新疗法.

科学领域:

肝病学和代谢研究.
药理学和自然产品的研究.

背景情况:

代谢功能障碍相关的脂肪肝疾病 (MAFLD),也称为非酒精性脂肪肝疾病 (NAFLD),是一种流行的慢性肝病,并有进展性并发症.
MAFLD可能导致严重的结果,如肝衰竭,需要进行肝移植.
目前对MAFLD的治疗选择有限,其病原性尚未完全理解.

研究的目的:

系统地审查用于治疗MAFLD的AMP激活蛋白激酶 (AMPK) 途径的天然活性植物代谢物的实验证据.
确定有前途的天然化合物,用于MAFLD的未来治疗开发.

主要方法:

进行了体内和体外研究的系统审查.
专注于调节AMPK通路的天然活性植物代谢物.
分析了与MAFLD治疗效果相关的证据.

主要成果:

自然活性植物代谢物显示出对MAFLD的治疗潜力.
AMPK途径是这些天然化合物的关键分子标.
证据支持使用植物代谢物来管理与MAFLD相关的脂质代谢障碍.

结论:

天然活性植物代谢物代表了对MAFLD的有前途,具有成本效益和可访问的治疗途径.
需要进一步的研究和配方开发,才能将这些发现转化为临床实践.
用植物化合物准AMPK途径为MAFLD管理提供了一个可行的策略.

关键词:

这就是AMPKK.在新的脂质生成中.脂肪酸氧化过程中的脂肪酸氧化.脂质新陈代谢脂质新陈代谢与代谢功能障碍相关的脂肪肝疾病.自然活性植物代谢物的植物代谢物.

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