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欧洲焦虑抑郁和主观耳之间的因果关系:双向孟德尔随机化研究

Cheng Zhong¹, Li-Hua Wang¹, Ying Dong²

¹Department of Otolaryngology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No.274, Zhijiang Middle Road, Jing'an District, Shanghai, China.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

|July 29, 2025

概括

研究了焦虑抑郁和耳风险之间的遗传联系. 研究结果表明,对心理痛苦的倾向增加了耳的可能性,支持在耳护理中整合心理健康.

科学领域:

遗传学是一个遗传学.
精神病学是一个精神病学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

耳是一种常见的听觉疾病,通常与心理困扰同时发生.
焦虑抑郁和耳之间的因果关系尚不清楚.
遗传因素可能在这些疾病的并发症中起作用.

研究的目的:

使用双向门德尔随机化 (MR) 方法调查焦虑抑郁和耳之间的潜在因果关系.
评估对焦虑抑郁症遗传倾向对耳风险的单向影响.
探索心理困扰和耳之间的遗传相关性.

主要方法:

两个样本的孟德尔随机化 (MR) 分析利用来自英国生物银行,IEU,EBI和FinnGen的大规模遗传数据.
基于全基因组意义,独立性和排除混因素的工具变量选择.
使用反变量加权 (IVW) 方法进行初级分析,其中包括加权中位数,MR-Egger和MR-PRESSO的灵敏度分析,以确保稳定性和评估变性.

主要成果:

核磁共振分析表明,焦虑抑郁症与发展耳风险增加之间存在显著的遗传相关性.
敏感性分析证实了研究结果的稳定性,并表明没有显著的类或异常值.
没有发现反向因果关系的证据,支持从焦虑抑郁症到耳的单向遗传影响.

结论:

对焦虑和抑郁症的遗传倾向显著增加了耳风险.
这些发现强调了将心理评估和干预措施纳入耳管理的重要性.
需要对不同种群进行进一步的研究,以阐明潜在的机制并确认这些关联.

关键词:

焦虑抑郁症是一种焦虑.因果关系是因果关系.门德尔的随机化声 (Tinnitus) 是一种听力障碍.

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