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对预测口腔状细胞癌复发的因素的评估

Ridhi Gupta¹, Vipin Arora¹, Pragya Shukla²

¹Department of ENT and Head Neck Surgery, University College of Medical Sciences, Delhi, India.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

|July 29, 2025

概括

在印度男性中,口腔癌复发很常见,骨入侵和积极边缘显著预测了它. 复发大大降低了生存率,强调了需要改进的管理策略.

科学领域:

在瘤学瘤学.
头部和部手术头部和部手术

背景情况:

口腔癌是印度男性癌症死亡的主要原因之一.
在初级治疗后,复发率在17-40%之间,患病率和死亡率显著.
陈述时的高级阶段,特别是淋巴结转移,预示着预后不佳.

研究的目的:

确定影响口腔癌患者局部区域和远程控制率的因素.
为了比较无病存活率,无复发存活时间和整体存活率.
分析复发的预测因素及其对患者结果的影响.

主要方法:

对接受手术的口腔癌患者的回顾性研究.
纳入标准:在德里GTBH和DSCI接受治疗的患者,随访时间至少2年.
分析组织病理学因素,包括骨干侵袭,边缘状态,淋巴血管侵袭 (LVI),外节延伸 (ECE) 和淋巴结阶段.

主要成果:

骨侵袭 (p=0.001) 和正边缘 (p=0.006) 是复发的重要预测因素.
淋巴血管侵袭 (LVI) 和淋巴结分期显著减少了无复发生存时间 (p<0.05).
脊髓炎和外延伸 (ECE) 与总生存率降低有关. 两年总生存率为36%,复发和68%,没有复发. 复发后的死亡率为62%.

结论:

先进的组织病理特征如骨参与,正边缘,LVI,ECE和先进的N阶段是口腔癌复发的关键预测因素.
复发始终与糟糕的结果和显著降低的生存率有关.
尽管取得了进展,但消除区域性复发风险仍然是一个挑战,需要有针对性的管理策略.

关键词:

复发的组织病理学.口腔状细胞癌的癌症.预测预测预测预测复发情况复发情况幸存的生存方式

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