神经界面技术的多维进步,用于外围神经的修复:从材料创新到临床翻译
Jianchao Wu1,2, Qixin Han3, Dingkun Gui4
1National Center for Orthopaedics, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Materials today. Bio
|July 29, 2025
概括
神经接口技术通过使双向通信成为可能,对外围神经损伤 (PNI) 有望. 材料和系统的进步正在改善功能,但对于广泛的临床应用仍然存在挑战.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 由于神经再生有限,外围神经损伤 (PNI) 显著损害了生活质量.
- 神经接口提供了一个有前途的功能重建策略,通过桥梁神经系统和外部设备.
研究的目的:
- 审查PNI的神经接口技术的研究进展和临床潜力.
- 分析材料,技术,临床验证和挑战方面的进展.
主要方法:
- 关于PNI的神经接口的高影响力研究的综合文献综述.
- 分析框架涵盖材料科学,技术创新,临床翻译和挑战.
主要成果:
- 材料从刚性演变为柔性,纳米复合材料,可生物降解和智能材料.
- 技术突破包括灵活的制造,无线系统,闭环控制和多式调制.
- 临床前和临床研究表明,在促进再生和恢复功能方面具有有效性,但面临着稳定性和炎症等挑战.
结论:
- 神经接口显示了PNI的治疗潜力,包括轴突再生和感觉运动恢复.
- 对于临床采用,必须解决长期稳定性,炎症和信号质量等挑战.
- 未来的研究需要适应性接口,智能系统和个性化治疗的跨学科整合.
更多相关视频
相关概念视频
Neuroplasticity
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Prosopagnosia
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...


