解决批发经销商对布普伦诺芬获取的障碍:PhARM-OUD专家小组的共识建议
Tyler J Varisco1,2, Douglas Thornton3,4, Taha Hussain3
1Pharmacy Addictions Research and Medicine Program, University of Texas at Austin College of Pharmacy, US.
Drug and alcohol dependence reports
|July 29, 2025
概括
批发分销障碍限制了对阿片类药物使用障碍 (OUD) 治疗的布普伦诺芬获取. 这项研究为药剂师,分销商和DEA制定了建议,以改善社区药房中布普伦诺芬的可用性.
科学领域:
- 药房实践 在药房实践中
- 公共卫生 公共卫生
- 药物使用障碍治疗 药物使用障碍治疗
背景情况:
- 抗阿片类药物治疗 (OAT) 尚未得到充分利用,只有不到25%的阿片类药物使用障碍 (OUD) 患者接受了它.
- 不到60%的药房储存布普伦诺芬,这是OUD治疗的关键药物,阻碍了患者的访问.
- 批发分销的挑战严重阻碍了社区药房中布普伦诺芬的可用性.
研究的目的:
- 制定协商一致的建议,旨在加强社区药房中用于OUD治疗的布普伦诺芬的批发分销.
- 解决影响布普伦诺啡因供应和可访问性的系统性障碍.
主要方法:
- 一项使用7个重点小组和德克萨斯州,加利福尼亚州和西弗吉尼亚州46名药剂师进行的定性诱导研究,以计划行为理论为指导.
- 对调查结果的分析,以创建一个详细介绍药店对布普伦诺芬供应的障碍的图片.
- 一项为期四轮的德尔菲研究,涉及22名药学,精神病学,药物分销和政策专家,以产生非立法建议.
主要成果:
- 分销商门被确定为布普伦诺芬配给,治疗中断,付款人的限制和对执法的恐惧的原因.
- 建议药剂师,毒品执法局 (DEA) 和分销商采取六项共识行动,以防止未来的布普伦诺芬供应中断.
- 该研究强调需要立即采取行动,以确保持续的布普伦诺芬可用性.
结论:
- 在没有新的立法的情况下,DEA和分销商可以实施改变,以改善布普伦诺啡的分销.
- 确保充足的布普伦诺芬供应对于使药剂师能够为OUD患者提供基本护理至关重要.
- 解决批发分销问题是扩大获得基于证据的OUD治疗的关键一步.
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