异常的拓性质和大脑大规模网络的功能结构合在初级角度闭眼光眼中
Yuanyuan Wang1,2, Chan Xiong3, Shenghong Li1,2
1Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Quantitative imaging in medicine and surgery
|July 29, 2025
概括
主要闭角光眼 (PACG) 患者表现出大脑网络连接的改变. 这项研究发现PACG中的功能结构合较弱,将大脑异常与视力和认知障碍联系起来.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 主要闭角光眼 (PACG) 与功能和结构性大脑异常有关.
- 了解这些神经变化对于管理PACG患者至关重要.
研究的目的:
- 在PACG中研究功能连接 (FC) 和结构连接 (SC) 网络的拓特性.
- 为了评估FC-SC合在PACG患者的大脑中的强度.
- 探索网络属性与临床/认知措施之间的相关性.
主要方法:
- 在47名PACG患者和48名健康对照 (HCs) 中利用静止状态fMRI和扩散张力成像.
- 使用AAL90地图和应用图形理论分析构建了大型FC和SC网络.
- 评估了全脑FC-SC合和与眼科和认知数据相关的网络指标.
主要成果:
- 与HC相比,PACG患者在FC网络中表现出较低的正常化聚类系数和小世界性,在SC网络中表现出较低的正常化特征路径长度.
- 在FC和SC网络中观察到异常节点属性 (程度,间距,效率),特别是在额叶,叶和叶.
- 在PACG组中发现了显著较弱的FC-SC合,与视觉敏度,疾病持续时间和认知分数相关.
结论:
- 患有PACG的患者表现出明显较弱的功能-结构大脑合,表明整合受损.
- 这些发现表明,PACG中存在广泛的网络层面的干扰,进步了对视神经损伤和认知缺陷的理解.
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