眼睛的变化与视觉皮层功能网络重组有关,在90天的头向下倾斜床休息后,视觉皮层功能网络重组
Linkun Cai1, Ke Lv2, Haijun Niu1
1School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Quantitative imaging in medicine and surgery
|July 29, 2025
概括
模拟的微重力降低了眼睛的血流和视觉敏度,同时增加了视觉皮层的连接性. 可能需要一个多月的恢复时间才能扭转这些太空飞行引起的变化.
科学领域:
- 太空医学 太空医学
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
背景情况:
- 微重力会导致液体的移动,可能导致神经眼科问题,如光盘胀.
- 模拟微重力对眼睛健康和视觉皮层功能的长期影响尚未完全理解.
研究的目的:
- 为了研究长时间模拟微重力对眼科变化的影响.
- 探索这些变化与视觉皮层功能重组之间的关系.
主要方法:
- 36名参与者接受了90天的头向下倾斜床休息 (HDTBR),模拟微重力.
- 进行了眼科测试 (视觉敏度,对比度敏感性) 和神经成像 (视觉皮层连接的fMRI,眼睛血流的3D-pcASL).
- 评估发生在基线,HDTBR后和28天康复后.
主要成果:
- 90天的HDTBR模拟导致眼睛血流 (OBF),近视敏度 (NVA) 和最佳校正视敏度 (BCVA) 显著下降.
- 功能连接 (FC) 在视觉皮层 (V1) 和V1和V3.3之间增加.
- 降低的BCVA与降低的OBF和增加的V1-V3FC相关.
结论:
- 降低OBF可能是模拟微重力下视力敏度下降的一个关键因素.
- 视觉皮层的功能重组似乎与视觉功能和OBF的改变有关.
- 延长恢复期,可能超过一个月,可能是必要的,以扭转这些太空飞行诱导的适应.
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