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10种与结直肠癌相关的细菌的特征代谢物概况

Yongqiang Liu¹, Wangli Mei², Xinyan Huang³

¹Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Frontiers in oncology

|July 29, 2025

概括

在结直肠癌 (CRC) 患者中,肠道细菌代谢物显著不同. 这些不同的代谢物和途径可以解释肠道微生物如何影响CRC进展,提供潜在的治疗点.

科学领域:

微生物学微生物学
代谢学代谢学代谢学
在瘤学瘤学.

背景情况:

与正常组织相比,结肠直肠癌 (CRC) 呈现出明显的瘤代谢结构,受营养缺乏,代谢物积累,酸度和缺氧的影响.
肠道微生物群的组成及其代谢物是影响CRC进展的已知的因素.
微生物代谢物可能会驱动CRC细胞中的代谢重编程,并调节瘤微环境.

研究的目的:

描述10种与CRC相关的细菌菌株的独特代谢物概况.
研究这些代谢物及其相关途径如何影响CRC发育.
为了确定参与CRC促进或抑制的潜在微生物机制.

主要方法:

在体外培养了10种特定的CRC相关细菌菌株 (每种10个复制品).
使用气体染色体质谱法 (GC-MS) 分析细菌培养超级生物.
在不同的细菌菌株和培养基上比较代谢物概况.

主要成果:

确定了10种CRC相关菌株中的每一种特征性代谢物概况,包括特定的糖类,氨基酸,胆汁酸和多胺.
在 *Lactobacillus* 种类中观察到糖类和有机酸的显著增加,在 *Bifidobacterium breve* 中观察到有益的多 (酸).
在 *Bifidobacterium* 种类和与CRC相关的病原体 (例如, *E. coli*, *P. anaerobius*, *F. necrophorum*, *F. nucleatum*) 中检测到氨基酸,胆汁酸和多氨基酸的显著变化.
发现代谢途径,特别是氨基酸和核酸代谢,受到显著影响.

结论:

研究的10种与CRC相关的细菌菌株表现出明显不同的代谢物概况和相关的代谢途径.
特定的微生物代谢物及其途径可能是肠道微生物群的CRC促进或抑制作用的关键调解者.
这些发现提供了关于肠道微生物群和结直肠癌代谢之间的复杂相互作用的见解.

关键词:

氨基酸代谢氨基酸代谢结肠直肠癌是什么意思我们的肠道微生物群.代谢途径的代谢途径代谢物的代谢物.

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