在炎症性皮肤疾病中研究转录年龄加速
Richie Jeremian1, Melissa Galati2, Rayyan Fotovati3
1Division of Dermatology, Department of Medicine, McGill University, Montréal, Canada.
概括
转录时钟显示在炎症性皮肤疾病 (如亚托皮炎和牛皮) 中,年龄加速. 这一发现有助于了解疾病的进展和皮肤疾病的衰老.
科学领域:
- 皮肤病学和分子生物学
- 遗传学和表观遗传学
- 衰老研究研究 衰老研究
背景情况:
- 在炎症性皮肤疾病中已知表观遗传衰老加速.
- 转录时钟,代表与年龄相关的基因表达,在这些条件下不太了解.
研究的目的:
- 为了研究转录时钟在hidradenitis suppurativa,亚托皮炎和斑块性牛皮的作用.
- 了解这些炎症性皮肤疾病的病理生理学和疾病轨迹.
主要方法:
- 利用7个时钟算法分析患者的基因表达 (n=37 hidradenitis suppurativa,n=27亚托皮炎,n=28斑块牛皮) 和健康受试者 (n=38).
- 损伤性,非损伤性和健康皮肤之间的转录年龄比较.
- 分析了FLG基因变异与在阿托皮性皮肤炎中转录年龄加速之间的关联.
主要成果:
- 7个转录时钟中的5个准确地预测了所有组的年龄.
- 在所有研究疾病中,与健康和非损伤性皮肤相比,在损伤性皮肤中观察到显著的衰老加速.
- FLG基因变异与阿托皮性皮肤炎患者的转录年龄加速相关.
- 时钟基因在与衰老,炎症和新陈代谢相关的途径中得到了丰富.
结论:
- 转录性衰老加速在炎症性皮肤疾病中很明显.
- 这些发现为探索皮肤疾病病理生理学中的与年龄相关的转录变化提供了基础.
- 转录时钟可以提供有关疾病轨迹和皮肤衰老过程的见解.
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