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在脏活检中内恶性瘤的临床病理学特征

Chen Yu Jamie Lee¹, Cynthia C Nast¹, Jean Hou¹

¹Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Glomerular diseases

|July 29, 2025

概括

内恶性瘤 (IGM) 是一种罕见的活检发现,通常表明晚期癌症预后不佳. 由于高死亡率,早期诊断至关重要.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
在瘤学瘤学.
病理学病理学病理学

背景情况:

内部恶性瘤 (IGM) 是活检中不常见的发现.
现有的IGM数据主要来自病例报告和小型系列,通常是死后的.
这项研究描述了IGM在脏活检样本中的临床病理特征.

研究的目的:

确定脏活检中发现的细胞内瘤 (IGM) 的临床病理特征.
为了区分IGM的血液学 (HEME) 和非血液学 (非HEME) 起源.
突出IGM的诊断挑战和预后影响.

主要方法:

从2000年1月到2023年6月诊断出IGM的脏活检病例的回顾性审查.
收集人口,临床和病理学数据.
将病例分为血液 (HEME) 和非血液 (非HEME) 恶性瘤组.

主要成果:

确定了9名IGM患者:5名血液淋巴瘤和4名转移性固体瘤.
所有患者呈现蛋白尿和血尿;89%患有功能障碍.
观察到高死亡率,88%的随访患者在平均69天内死亡.
非HEME IGM显示出来自恶性细胞的毛囊外超细胞性,与HEME病例不同.

结论:

IGM是脏活检中罕见但至关重要的发现,表明了晚期恶性瘤和不良预后.
病理学家必须认识到IGM是潜在的模仿其他淋巴细胞疾病.
准确的诊断需要完整的临床病史;由于死亡率高,IGM的识别需要紧急医疗护理.

关键词:

淋巴细胞疾病是什么?淋巴细胞突炎是什么?内质恶性瘤是什么脏活检脏活检转移到脏中的转移.淋巴瘤是一种淋巴瘤.

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