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德斯莫普列辛用于儿童夜间尿尿症
Deirdre Hahn1,2, Fiona Stewart3, Gayathri Raman1,2
1Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia.
The Cochrane database of systematic reviews
|July 29, 2025
概括
与安慰剂相比,德斯莫普林素 (床上药) 可能会增加儿童的干燥夜晚,但证据质量较低. 报警疗法可能提供比desmopressin更好的长期结果.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 药理干预对尿尿注射的药理干预
- 基于证据的医学基于证据的医学.
背景情况:
- 夜间尿尿 (床上尿) 影响了很大一部分儿童,导致了相当大的社会和情绪上的痛苦.
- 自20世纪70年代以来,德斯摩普林素一直是尿床的主要治疗方法,因此需要更新有效性和安全性审查.
- 本综述提供了对随机对照试验的最新分析,这些试验评估了儿童夜间尿液的德斯莫普林.
研究的目的:
- 评估德斯莫普林素在治疗5至16岁儿童夜间尿泡症的有效性和安全性.
- 为了比较德斯莫普雷辛单一疗法与安慰剂,警报疗法和其他药理学药物.
- 评估德斯莫普林素与其他治疗,如警报疗法和抗胆固醇药物结合的疗效.
主要方法:
- 随机和准随机对照试验的系统审查和元分析.
- 搜索了多个数据库,包括Cochrane失禁专业注册,MEDLINE和ClinicalTrials.gov,直到2023年1月.
- 包括95项与8473名参与者的研究,独立评估数据提取和偏差风险.
主要成果:
- 与安慰剂相比,德斯莫普林可能会增加每周干燥夜晚的数量 (低确定性证据),并且可能会增加连续14个干燥夜晚的数量 (中等确定性证据).
- 有证据表明,德斯莫普林在减少湿夜或实现干夜方面与警报疗法有不确定的区别,确定性低至非常低.
- 用德斯莫普林和警报疗法的联合治疗可能会减少湿夜,增加连续干夜,但证据确定性低至非常低.
结论:
- 与安慰剂相比,德斯莫普林素可能会改善尿症儿童的夜间干燥,尽管证据质量有限.
- 与德斯摩辛相比,警报疗法可能提供更好的长期结果,证据中等确定性.
- 总体来说,关于德斯莫普雷辛疗效的证据质量和与其他治疗方法的比较主要是低或非常低,这凸显了进一步高质量的研究的需要.
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