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帕洛斯米亚嗅觉功能障碍结果评级 (DisODOR) 的二次验证:随机临床试验的分析

Andrew M Peterson¹, Dorina Kallogjeri¹, Aseeyah A Islam¹

¹Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine in St. Louis, MO, USA.

The Annals of otology, rhinology, and laryngology

|July 29, 2025

概括

迪索多 (DisODOR) 是一种患者报告的帕洛斯米亚结局指标,有效地跟踪治疗反应. 这项研究证实了其在临床试验中的可靠性和响应性,用于嗅觉扭曲.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经学神经学
临床结果研究研究

背景情况:

帕洛斯米亚是一种气味扭曲,缺乏经过验证的疾病特异性患者报告结果措施 (PROMs) 来跟踪治疗的有效性.
迪索多 (DisODOR) 是唯一对帕洛斯米亚 (parosmia) 进行验证的PROM,但其对干预的响应性需要进一步研究.

研究的目的:

评估DisODOR仪器在干预后对帕洛斯米亚患者的变化反应的反应性.
在临床试验环境中评估DisODOR的内部一致性和测试-重新测试可靠性.

主要方法:

一个双盲,安慰剂对照的随机临床试验 (RCT),涉及经过恒星关节阻塞的帕洛斯米亚患者.
迪索多在基线和3个月后进行了治疗;还收集了临床总体印象 - 改善 (CGI-I) 评分.
响应变化是主要结果,内部一致性 (克朗巴赫α) 和测试-重新测试可靠性 (皮尔森相关性) 是次要结果.

主要成果:

在改善类别中观察到DisODOR得分的显著变化,大效果大小 (eta平方 = .63) 表明强烈的响应性.
证明了出色的内部一致性 (克朗巴赫α = .91) 和强大的测试重试可靠性 (皮尔森相关性 = .85).
报告显著改善的参与者在DisODOR得分中平均变化为-47.

结论:

迪索多表现出对变化的强有力的反应能力,支持其用于监测帕洛斯米亚治疗结果.
该仪表表现出优异的内部一致性和强大的测试复试可靠性,验证了其在临床实践和研究中的实用性.
迪索多 (DisODOR) 是量化帕洛斯米亚严重程度和治疗反应的宝贵工具,解决了该领域的关键需求.

关键词:

嗅觉嗅觉是一种嗅觉.嗅觉功能障碍嗅觉功能障碍耳鼻喉科耳鼻喉科耳鼻喉科患者报告的结果.鼻科鼻科是指鼻科的专家.味道味道味道味道味道

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