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卷度MRI比较MOGAD的纵向变化与NMOSD,MS和健康对照,以及残疾人协会
Amy Kunchok1, Moein Amin1, Tatchaporn Ongphichetmetha1
1Department of Neurology, Mellen Center for Multiple Sclerosis, Cleveland, OH, USA.
Annals of neurology
|July 29, 2025
概括
与髓寡细胞糖蛋白抗体相关疾病 (MOGAD) 相比,健康对照群的脑容量损失更快,与MS和NMOSD相比,有明显的缩模式. 在MOGAD中体积损失与残疾相关.
科学领域:
- 神经免疫学 神经免疫学
- 神经成像是一种神经成像.
- 神经学 神经学
背景情况:
- 髓寡细胞糖蛋白抗体相关疾病 (MOGAD) 是一种炎症性脱髓化疾病,具有与多发性硬化症 (MS) 和神经omyelitis optica光谱障碍 (NMOSD) 重叠的特征.
- 卷积磁共振成像 (vMRI) 对于评估神经炎症疾病中大脑缩至关重要.
研究的目的:
- 将MOGAD中的vMRI发现与MS,NMOSD和健康对照 (HC) 进行比较.
- 在MOGAD中调查大脑体积变化与临床残疾之间的关系.
主要方法:
- 标准化vMRI对32名MOGAD患者,160名MS患者,49名NMOSD患者和52名HC患者进行了标准化vMRI.
- 混合线性模型分析了纵向体积变化,将MOGAD与其他组进行比较.
- 使用患者决定的疾病步骤 (PDDS),手工灵巧度 (MDT),步行速度 (WST),处理速度 (PST) 和对比敏感性测试 (CST) 来评估残疾.
主要成果:
- 与HC相比,MOGAD表现出全球大脑体积损失的速度更快.
- 根据MOGAD的数据,在基线与MS相比,保持了深灰色物质 (thalamus,caudate,putamen) 的数量.
- 在长度上,MOGAD增加了侧腔室分数,但与NMOSD和MS相比,海马和上带区域 (UCCA) 损失较少.
- 在MOGAD中,UCCA损失与PDDS和CST相关;整个大脑部分与PDDS和PST相关;和LVF与PDDS相关.
结论:
- 与HC相比,MOGAD显示显著的纵向大脑体积损失.
- 存在明显的区域性缩模式,MOGAD显示与MS相比,深灰质相对保持良好,与MS和NMOSD相比,UCCA的保存更大.
- 尽管整体缩较少,但MOGAD中大脑体积损失与临床残疾有关,这凸显了vMRI在了解疾病进展和影响方面的重要性.
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