炎症生物标志物作为脑内动脉瘤复发的预后指标,在支架辅助线圈栓塞后
Jie Wei1, Jinghui Lin1, Junjun Zhang1
1Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Immunity, inflammation and disease
|July 29, 2025
概括
血IL-2,IL-10,IL-17和IFN-γ水平升高与在支架辅助线圈栓塞 (SACE) 后复发的内动脉瘤 (IAs) 有关. 这些细胞因子可能有助于预测IA复发风险.
科学领域:
- 神经内分泌学神经内分泌学
- 免疫学 免疫学 免疫学
- 血管外科 血管外科
背景情况:
- 在支架辅助线圈栓塞 (SACE) 后,内动脉瘤 (IA) 的复发是一个临床挑战.
- 通过调节性T细胞计数和血细胞因子来评估系统性炎症,研究其在IA复发中的作用.
研究的目的:
- 分析血液调节性T细胞计数和血细胞因子水平.
- 确定系统性炎症标志物和SACE后IA复发之间的关联.
主要方法:
- 在189名患者的回顾性研究中,有220名未破裂的IA.
- 使用雷蒙德-罗伊尺度将其分类为闭塞和复发群.
- 单变量分析,逻辑回归和ROC曲线分析用于细胞因子水平 (IL-2,IL-10,IL-17,IFN-γ).
主要成果:
- 血IL-2,IL-10,IL-17和IFN-γ水平的升高在复发组观察到与封闭组相比.
- IL-10,IL-17和IFN-γ被确定为IA复发的独立预测因子.
- 一种IL-2,IL-10,IL-17和IFN-γ的组合实现了0.761的AUC来预测复发风险.
结论:
- 血IL-2,IL-10,IL-17和IFN-γ的升高与SACE后的复发性内动脉瘤有关.
- 最初的系统性炎症水平似乎是IA复发的重要因素.
- 联合细胞因子分析可能有助于预测SACE后IA复发.
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