迪恩ोजे斯特的使用和患乳腺癌和妇科癌症的风险:一项全国性基于人口的研究
Hoyol Jhang1, Saerom Kim1, Hyun-Tae Park2
1Department of Public Health, Korea University, Seoul, Republic of Korea.
概括
在患有子宫内膜异位症的妇女中,与GnRH激动剂相比,Dienogest的使用没有增加乳腺,子宫内膜或卵巢管癌的风险. 这项研究支持dienogest用于子宫内膜异位症治疗的瘤安全性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
背景情况:
- 子宫内膜异位症会影响生育年龄的女性,通常用荷尔蒙疗法治疗.
- 迪恩ोजे斯特和淋巴激素释放激素 (GnRH) 激动剂是常见的治疗方法,但它们的长期瘤安全性需要评估.
- 有关这些治疗对妇科和乳腺癌风险的潜在影响存在担忧.
研究的目的:
- 在被诊断患有子宫内膜异位症的妇女中调查dienogest暴露与乳腺,子宫内膜和卵巢管癌的风险之间的关联.
- 为了比较使用dienogest的患者的癌症风险与用GnRH激动剂治疗的患者.
主要方法:
- 一项全国性的回顾性队列研究,利用韩国国家健康保险审查和评估服务数据库 (2012-2023年).
- 包括20-49岁的女性患有子宫内膜异位症,比较使用dienogest (≥6个月) 和使用GnRH激动剂的女性.
- 治疗权重的反向概率 (IPTW) 用于队列平衡和考克斯比例危险模型来估计调整的危险比率 (aHR).
主要成果:
- 与GnRH激动剂相比,使用dienogest与乳腺癌 (aHR 1.01),子宫内膜癌 (aHR 0.84) 或卵巢管癌 (aHR 0.92) 的风险增加无关.
- 经过0.5-1.5年使用dienogest (aHR为0.72),观察到乳腺癌风险降低,尽管长期关联不一致.
- 这项研究包括一个庞大的队列:14,647名使用dienogest的用户和181,587名使用GnRH激动剂的用户用于乳腺癌分析.
结论:
- 在患有子宫内膜异位症的妇女中使用dienogest证明了瘤安全性,与GnRH激动剂相比,乳腺,子宫内膜或卵巢管癌风险没有显著增加或减少.
- 这些研究结果支持使用dienogest来治疗子宫内膜异位症.
- 建议进行进一步的长期研究,以充分阐明持续时间对癌症风险的影响.
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