概括
加快型MRI序列 (aGRE,aSWI) 显著减少了粉样蛋白相关成像异常-出血 (ARIA-H) 查的扫描时间,维持了诊断性能,但对评级者协议和图像质量有所减少.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 抗粉样β免疫疗法需要经常对ARIA-H (大脑微出血/表面 siderosis) 进行MRI 查.
- 目前的MRI序列 (GRE,SWI) 是耗时的,可能会限制患者的入学和增加运动工件.
- 加快的MRI技术可以提高查效率和患者的吞吐量.
研究的目的:
- 为了评估回声平面成像 (EPI) 的诊断性能,加速GRE (aGRE) 和SWI (aSWI) 替代物用于检测CMB和SS.
- 在灵敏度,特异性和预测值方面,比较加速序列与标准GRE和SWI.
- 评估加速对图像质量,运动和评分协议的影响.
主要方法:
- 对50名接受FDG PET-3TMRI的患者进行了回顾性分析.
- 标准GRE (90年代) 和SWI (192年代) 与EPI加速aGRE (13年代) 和aSWI (33年代) 的比较.
- 三位神经放射学家对CMB和SS检测,图像质量和运动进行独立评估,并计算AUC,PPV,NPV和评分器间一致性.
主要成果:
- 在所有序列中,CMB (0.84-0.94) 和SS (0.89-1.00) 的AUC总值都很好,标准方法和加速方法之间没有显著差异.
- 高负预测值 (96.5%-100%) 对于aGRE和aSWI.
- 与标准相比,加速序列的分级间协议略有减少,并降低了感知到的图像质量,尽管aSWI显示的动作较少.
结论:
- EPI加速的aGRE和aSWI序列为ARIA-H查提供了相当大的时间节省 (86%和83%).
- 这些加速序列显示了与标准GRE和SWI用于检测CMB和SS的可比的诊断性能.
- 虽然加速序列减少了评级者同意和感知到的图像质量,但它们代表了有效的ARIA-H选的可行选择.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的疾病与粉样蛋白相关的成像异常抗粉胺-β免疫疗法免疫疗法大脑微型出血.声波平面成像技术的成像渐变回忆回忆回声的回声表面的 siderosis 的作用.敏感度加权的成像成像方法更多相关视频
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