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Updated: Jun 17, 2026

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设计,优化和生物评估一种基于昆林的新型POLRMT抑制剂,用于前列腺癌治疗

Xinnan Li1, Lihua Liu1, Dazhi Feng1

  • 1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

Journal of medicinal chemistry
|July 29, 2025
PubMed
概括

一种新型化合物YH-0623有效抑制线粒体RNA聚合酶 (POLRMT),并在前列腺癌模型中显示出显著的抗增殖作用. 这种口服可用的POLRMT抑制剂在前列腺癌治疗中显示出有前途的治疗潜力.

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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...