基于加多的对比剂对儿童的安全性:系统性审查和元分析
Ok Jeong Yu1, Pyeong Hwa Kim1, Hee Mang Yoon1
1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-Gu, Seoul 05505, Republic of Korea.
Radiology
|July 29, 2025
概括
基于加多的对比剂 (GBCA) 在儿科MRI扫描中显示低的不良反应率. 没有报告性系统性纤维化 (NSF) 的病例,但在线性和宏循环剂之间,加多沉积有所不同.
科学领域:
- 儿科放射学 儿科放射学
- 神经辐射学神经辐射学
- 药物监督 药物监督 药物监督
背景情况:
- 关于加多基对比剂 (GBCA) 在儿科对比增强MRI中持续存在的安全问题.
- 评估儿童和青少年的GBCA安全性对于临床实践至关重要.
研究的目的:
- 系统地审查和元分析GBCA安全性,在儿童患者接受了对比增强MRI.
- 评估与GBCA相关的不良药物反应 (ADRs),神经系统性纤维化 (NSF) 和大脑加多沉积.
主要方法:
- 系统审查和对研究的元分析,截至2023年11月.
- 与GBCA相关的不良反应和NSF的综合发病率.
- 线性混合效应模型用于评估大脑加多沉积 (DN-pons SI比) 和GBCA类型.
主要成果:
- 与GBCA相关的急性 (0.25%生理性,0.13%过敏性) 和延迟的 (0.04%) 副作用的发生率较低.
- 在4895名患者中没有报告NSF病例.
- 在GBCA类型 (线性与宏循环) 和大脑中的加多沉积之间显著的相互作用.
结论:
- 儿童使用GBCA与不良反应的发病率较低有关.
- 在审查的儿科患者群体中没有观察到NSF.
- 与宏环剂相比,线性GBCA与大脑加多沉积的相关性不同.
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