2019年冠状病毒病对视神经炎患者的影响:单中心回顾性队列研究
Rong Yan1, Yanjun Guo1, Chao Meng1
1Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, China.
概括
COVID-19感染可能会引发特定类型的视神经炎 (ON),增加急性传播性脑膜炎相关的ON (ADEM-ON). 大多数患者会出现严重的视力丧失,但随着及时的免疫治疗,他们会恢复良好.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
背景情况:
- COVID-19和视神经炎 (ON) 之间的联系还没有得到很好的定义.
- 关于COVID-19后ON的临床特征和结果的数据有限.
研究的目的:
- 为了调查COVID-19对ON亚型的影响.
- 为了确定近期COVID-19感染的患者的ON预后.
主要方法:
- 一项回顾性队列研究比较了最近的COVID-19和没有COVID-19的急性ON患者在奥米克朗波期间.
- 一个历史性的COVID-19前队列作为对照组.
主要成果:
- 在55名ON患者中,有12名近期患有COVID-19.
- 与COVID-19相关的ON显示ADEM-ON增加 (25%对0%) 和AQP4-ON减少 (0%对31.4%).
- 患者呈现眼睛疼痛 (75%) 和呼吸道症状 (60%); 66.7% 患有严重的视力损失,但 83.3% 在免疫治疗后恢复良好,一次复发.
结论:
- 在ON中,COVID-19可能会诱导独特的自身免疫反应,特别是增加ADEM-ON.
- 及时的免疫疗法导致了有利的视觉结果,尽管最初的严重视力丧失.
- 这些发现增强了对COVID-19神经眼部并发症的理解.
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