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相关概念视频

Protein Organization01:24

Protein Organization

7.1K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
7.1K
Conserved Binding Sites01:49

Conserved Binding Sites

4.4K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.4K
Protein-protein Interfaces02:04

Protein-protein Interfaces

13.3K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
13.3K
Protein Families02:47

Protein Families

15.8K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.8K
Protein and Protein Structure02:15

Protein and Protein Structure

81.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
81.4K
Protein and Protein Structures02:15

Protein and Protein Structures

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相关实验视频

Updated: Sep 13, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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一个在线服务器,通过预测结构来进行几何意识的蛋白质功能注释.

Jialin Zou1, Qianmu Yuan1,2, Yuedong Yang3

  • 1School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, China.

Methods in molecular biology (Clifton, N.J.)
|July 29, 2025
PubMed
概括
此摘要是机器生成的。

GPSFun是一个新的网络服务器,用于蛋白质功能注释,预测结合点,基因本体学等. 它解决了对越来越多的蛋白质序列的功能注释的差距.

关键词:
在GPSFun网络服务器上.基因本体论的基因本体论结合质的结合点.蛋白质功能的预测和预测蛋白质的可溶性 蛋白质的可溶性亚细胞位置 亚细胞位置

更多相关视频

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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相关实验视频

Last Updated: Sep 13, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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科学领域:

  • * 生物信息学是一门学科.
  • * 计算生物学 * 计算生物学
  • * 结构生物学 * 结构生物学

背景情况:

  • *确定蛋白质功能对于各种生物研究领域至关重要,包括元基因组学,疾病机制研究和药物发现.
  • *目前用于蛋白质功能的生物化学方法通常是低效和昂贵的,在注释大量可用的蛋白质序列时造成瓶.

研究的目的:

  • * 推出GPSFun,这是一款新的Web服务器,旨在快速准确地注释蛋白质序列功能.
  • * 提供全面的,几何意识的功能预测,包括联结位,基因本体学,亚细胞局部化和蛋白质溶解性.

主要方法:

  • * 开发一个用于蛋白质功能注释的Web服务器 (GPSFun).
  • *利用几何感知算法来预测各种功能属性.
  • *从广泛的瑞士-Prot注释中创建一个补充数据库 (GPSiteDB).

主要成果:

  • * GPSFun提供了一个用户友好的Web界面,可以访问详细的蛋白质功能注释.
  • * 该工具成功标注了超过568,000个瑞士-Prot蛋白质的配体结合部位,形成了GPSiteDB数据库.
  • *注释包括对蛋白质结合部位,基因本体学,亚细胞位置和蛋白质溶解度的预测.

结论:

  • * GPSFun为加速生物研究中的蛋白质功能注释提供了有价值和高效的资源.
  • * 集成的GPSiteDB数据库提供了丰富的资源,用于探索蛋白质功能和联结特征.
  • * 开发的方法提高了对蛋白质在各种生物环境中的作用的理解.